abstract：:Reductionist in vitro T cell assays have identified metabolic pathways critical for T cell function within the tumor microenvironment. We discuss the challenges of testing these concepts using in vivo tumor models. ...

journal_title：Cell metabolism

authors： Ecker C,Riley JL

更新日期：2018-08-07 00:00:00

abstract：:We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed interleukin-6 (IL-6)-mediated peripheral inflammation, coincident with altered hepatic glucose processing and sleep. Tumor-bearing mice were hyperphagic, had reduced s...

journal_title：Cell metabolism

authors： Borniger JC,Walker Ii WH,Surbhi,Emmer KM,Zhang N,Zalenski AA,Muscarella SL,Fitzgerald JA,Smith AN,Braam CJ,TinKai T,Magalang UJ,Lustberg MB,Nelson RJ,DeVries AC

更新日期：2018-07-03 00:00:00

abstract：:Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in ...

journal_title：Cell metabolism

authors： Arner P,Andersson DP,Bäckdahl J,Dahlman I,Rydén M

更新日期：2018-07-03 00:00:00

abstract：:Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...

journal_title：Cell metabolism

authors： Lundberg JO,Carlström M,Weitzberg E

更新日期：2018-07-03 00:00:00

abstract：:In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an ov...

journal_title：Cell metabolism

authors： McGlone ER,Tan TM

更新日期：2018-06-05 00:00:00

abstract：:Cancer cells frequently hijack normal metabolic pathways to promote their growth and metastasis. Two recent papers by Knott et al. (2018) and Pavlova et al. (2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulat...

journal_title：Cell metabolism

authors： Luo M,Brooks M,Wicha MS

更新日期：2018-05-01 00:00:00

abstract：:Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defec...

journal_title：Cell metabolism

authors： Chen Q,Kirk K,Shurubor YI,Zhao D,Arreguin AJ,Shahi I,Valsecchi F,Primiano G,Calder EL,Carelli V,Denton TT,Beal MF,Gross SS,Manfredi G,D'Aurelio M

更新日期：2018-05-01 00:00:00

abstract：:RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are appr...

journal_title：Cell metabolism

authors： Crooke ST,Witztum JL,Bennett CF,Baker BF

更新日期：2018-04-03 00:00:00

abstract：:Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding mice a low-protein (Low PROT) isocaloric diet but not a low-carbohydrate (Low CHO) diet reduced tumo...

journal_title：Cell metabolism

authors： Rubio-Patiño C,Bossowski JP,De Donatis GM,Mondragón L,Villa E,Aira LE,Chiche J,Mhaidly R,Lebeaupin C,Marchetti S,Voutetakis K,Chatziioannou A,Castelli FA,Lamourette P,Chu-Van E,Fenaille F,Avril T,Passeron T,Patterson

更新日期：2018-04-03 00:00:00

abstract：:In this issue of Cell Metabolism, Macdougall et al. (2018) identify two subsets of conventional dendritic cells in visceral adipose tissue and demonstrate that these subsets engage distinct adipocyte-associated signaling pathways to drive their tolerogenic phenotypes in the lean state. ...

journal_title：Cell metabolism

authors： LaMarche NM,Lynch L

更新日期：2018-03-06 00:00:00

abstract：:Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The dense network of islet capillaries includes the islet pericyte, a cell that has barely been studied. Here we show that islet pericytes help control local blood flow by adjusting islet capillary diameter. Islet pericytes cove...

journal_title：Cell metabolism

authors： Almaça J,Weitz J,Rodriguez-Diaz R,Pereira E,Caicedo A

更新日期：2018-03-06 00:00:00

abstract：:You are what you eat; but when you eat also seems to be important for a healthy metabolism. In this issue of Cell Metabolism, Benegiamo et al. (2018) uncover a mechanism by which the RNA-binding protein NONO promotes the time-of-day-dependent expression of key metabolic genes at a post-transcriptional level in respons...

journal_title：Cell metabolism

authors： Torres M,Kramer A

更新日期：2018-02-06 00:00:00

abstract：:Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contrast, genetic elimin...

journal_title：Cell metabolism

authors： Ussher JR,Campbell JE,Mulvihill EE,Baggio LL,Bates HE,McLean BA,Gopal K,Capozzi M,Yusta B,Cao X,Ali S,Kim M,Kabir MG,Seino Y,Suzuki J,Drucker DJ

更新日期：2018-02-06 00:00:00

abstract：:Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance. Inhibiting JAK/STAT3 blocks BCSC self...

journal_title：Cell metabolism

authors： Wang T,Fahrmann JF,Lee H,Li YJ,Tripathi SC,Yue C,Zhang C,Lifshitz V,Song J,Yuan Y,Somlo G,Jandial R,Ann D,Hanash S,Jove R,Yu H

更新日期：2018-01-09 00:00:00

abstract：:Regulatory T cells maintain tolerance and prevent autoimmunity, but their suppressive effects can hinder immune responses against cancer. In Nature Immunology, Maj et al., 2017 report that regulatory T cells can execute these actions through the nucleoside adenosine even after cell death. ...

journal_title：Cell metabolism

authors： Beier UH

更新日期：2018-01-09 00:00:00

abstract：:Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we show that p62 deficiency in stromal fibroblasts promotes resistance to glutamine deprivation by the di...

journal_title：Cell metabolism

authors： Linares JF,Cordes T,Duran A,Reina-Campos M,Valencia T,Ahn CS,Castilla EA,Moscat J,Metallo CM,Diaz-Meco MT

更新日期：2017-12-05 00:00:00

abstract：:With the identification of its receptor in a highly specific region of the brain, interesting issues come to light regarding the normal physiological functions of GDF15, a secreted protein long identified as a biomarker of diverse disease states. ...

journal_title：Cell metabolism

authors： O'Rahilly S

更新日期：2017-12-05 00:00:00

abstract：:In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support c...

journal_title：Cell metabolism

authors： Shan M,Lyssiotis CA

更新日期：2017-12-05 00:00:00

abstract：:Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...

journal_title：Cell metabolism

authors： Miller A,Nagy C,Knapp B,Laengle J,Ponweiser E,Groeger M,Starkl P,Bergmann M,Wagner O,Haschemi A

更新日期：2017-11-07 00:00:00

abstract：:While intermittent or periodic fasting provides a variety of favorable health benefits, the molecular mediators of these effects are poorly understood. In this issue of Cell Metabolism, Li and colleagues (2017) highlight the role of gut microbiota in mediating benefits of intermittent fasting through activation of adi...

journal_title：Cell metabolism

authors： Haas JT,Staels B

更新日期：2017-10-03 00:00:00

abstract：:The "Rosies" of Cell Metabolism persist as a new generation enters the stage. With inspiration from this issue's cover art, we celebrate young and diverse scientists and the mentorship that has guided them throughout. Their stories come from different corners of the world but are tied together by a common thread of te...

journal_title：Cell metabolism

authors：

更新日期：2017-09-05 00:00:00

abstract：:The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β cells has recently been questioned as small amounts of C-peptide are detectable in patients with long-standing disease. We analyzed protein and gene expression levels for proinsulin, insulin, C-peptide, and islet amyloid poly...

journal_title：Cell metabolism

authors： Wasserfall C,Nick HS,Campbell-Thompson M,Beachy D,Haataja L,Kusmartseva I,Posgai A,Beery M,Rhodes C,Bonifacio E,Arvan P,Atkinson M

更新日期：2017-09-05 00:00:00

abstract：:Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...

journal_title：Cell metabolism

authors： Huang Z,Zhong L,Lee JTH,Zhang J,Wu D,Geng L,Wang Y,Wong CM,Xu A

更新日期：2017-09-05 00:00:00

abstract：:A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of th...

journal_title：Cell metabolism

authors： Stefan N,Schick F,Häring HU

更新日期：2017-08-01 00:00:00

abstract：:Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant genomes or the absolute number of wild-type molecules determines if ox...

journal_title：Cell metabolism

authors： Jiang M,Kauppila TES,Motori E,Li X,Atanassov I,Folz-Donahue K,Bonekamp NA,Albarran-Gutierrez S,Stewart JB,Larsson NG

更新日期：2017-08-01 00:00:00

abstract：:High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL prep...

journal_title：Cell metabolism

authors： Kopecky C,Michlits G,Säemann MD,Weichhart T

更新日期：2017-07-05 00:00:00

abstract：:Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is...

journal_title：Cell metabolism

authors： Puleston DJ,Villa M,Pearce EL

更新日期：2017-07-05 00:00:00

abstract：:Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exerci...

journal_title：Cell metabolism

authors： Jordan SD,Kriebs A,Vaughan M,Duglan D,Fan W,Henriksson E,Huber AL,Papp SJ,Nguyen M,Afetian M,Downes M,Yu RT,Kralli A,Evans RM,Lamia KA

更新日期：2017-07-05 00:00:00

abstract：:In animal models, the physiological systems involved in metabolic homeostasis exhibit a sex difference. Investigators often use male rodents because they show metabolic disease better than females. Thus, females are not used precisely because of an acknowledged sex difference that represents an opportunity to understa...

journal_title：Cell metabolism

authors： Mauvais-Jarvis F,Arnold AP,Reue K

更新日期：2017-06-06 00:00:00

abstract：:Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...

journal_title：Cell metabolism

authors： Gabriel BM,Zierath JR

更新日期：2017-05-02 00:00:00

abstract：:Hallmarks of aging that negatively impact health include weight gain and reduced physical fitness, which can increase insulin resistance and risk for many diseases, including type 2 diabetes. The underlying mechanism(s) for these phenomena is poorly understood. Here we report that aging increases DNA breaks and activa...

journal_title：Cell metabolism

authors： Park SJ,Gavrilova O,Brown AL,Soto JE,Bremner S,Kim J,Xu X,Yang S,Um JH,Koch LG,Britton SL,Lieber RL,Philp A,Baar K,Kohama SG,Abel ED,Kim MK,Chung JH

更新日期：2017-05-02 00:00:00

abstract：:As a preview of the upcoming Cell Symposium on Exercise Metabolism in Gothenburg, Sweden, May 21-23 (http://cell-symposia.com/exercisemetabolism-2017/), several of our speakers and other Cell Press exercise enthusiasts share a wide range of experiences from bench pressing goals to bench research insights. ...

journal_title：Cell metabolism

authors：

更新日期：2017-05-02 00:00:00

abstract：:During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis. ...

journal_title：Cell metabolism

authors： Garcia-Irigoyen O,Moschetta A

更新日期：2017-04-04 00:00:00

abstract：:Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur exclusively via the replication of existing beta cells, but clinically meaningful restoration of human beta cell mass by proliferation has never been achieved. We discovered a population of immature beta cells that is present through...

journal_title：Cell metabolism

authors： van der Meulen T,Mawla AM,DiGruccio MR,Adams MW,Nies V,Dólleman S,Liu S,Ackermann AM,Cáceres E,Hunter AE,Kaestner KH,Donaldson CJ,Huising MO

更新日期：2017-04-04 00:00:00

abstract：:T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced...

journal_title：Cell metabolism

authors： Chapman NM,Chi H

更新日期：2017-03-07 00:00:00

abstract：:The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic ...

journal_title：Cell metabolism

authors： Robinson MM,Dasari S,Konopka AR,Johnson ML,Manjunatha S,Esponda RR,Carter RE,Lanza IR,Nair KS

更新日期：2017-03-07 00:00:00

abstract：:Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 mon...

journal_title：Cell metabolism

authors： Greggio C,Jha P,Kulkarni SS,Lagarrigue S,Broskey NT,Boutant M,Wang X,Conde Alonso S,Ofori E,Auwerx J,Cantó C,Amati F

更新日期：2017-02-07 00:00:00

abstract：:Diabetes is a growing epidemic, and many patients depend on insulin injections to control the disease and minimize long-term complications. In a recent manuscript published in Science, Xie et al. (2016) generate insulin-producing cells from a somatic embryonic kidney cell line through minimal genetic modification capa...

journal_title：Cell metabolism

authors： Hebrok M

更新日期：2017-02-07 00:00:00

abstract：:One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense. Both within eukaryotic cells and across organs, 1C metabolic r...

journal_title：Cell metabolism

authors： Ducker GS,Rabinowitz JD

更新日期：2017-01-10 00:00:00

abstract：:Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about tempor...

journal_title：Cell metabolism

authors： Wang J,Mauvoisin D,Martin E,Atger F,Galindo AN,Dayon L,Sizzano F,Palini A,Kussmann M,Waridel P,Quadroni M,Dulić V,Naef F,Gachon F

更新日期：2017-01-10 00:00:00